Dr Lang Tran

Head of Toxicology Section – Principal Toxicologist

Institute of Occupational Medicine
8 Roxburgh Place
Edinburgh
EH8 9SU
UK

Research Expertise

The UK Department for International Development (DfID) commissioned the Institute of Occupational Medicine to conduct toxicological tests to determine the relative safety of the Montserrat volcanic ash. These included an inhalation experiment conducted in rats by IOM. This experiment was designed by Dr Lang Tran with the objective of testing the null hypothesis that, dose for dose, inhaled volcanic ash causes no greater pulmonary inflammation than a benchmark, low toxicity, control dust.

Relevant Publications

Monteiro-Riviere, N.A., Tran, C.L. 2007. Nanotoxicology: characterization, dosing and health effects. New York: Informa.

Donaldson, K, Borm, P.J.A., Oberdoerster, G., Pinkerton, K.E., Stone, V., Tran, C.L. 2007. Concordance between in vitro and in vivo dosimetry in the pro-inflammatory effects of low toxicity, low solubility particles: the key role of the proximal alveolar region. Inhalation Toxicology, 20:53 – 62

Duffin, R., Tran, L., Brown, D., Stone, V., Donaldson, K. 2007. Pro inflammogenic effects of low-toxicity and metal nanoparticles in vivo and in vitro: highlighting the role of particle surface area and surface reactivity . Inhalation Toxicology, 19: 849-856.

Kuempel, E.D., Tran, C.L., Castranova, V., Bailer, A.J. 2007. Response to Dr Norfeld’s letter. Letter. Inhalation Toxicology; 19: 197-198.

Cullen, R.T., Jones, A.D., Miller, B.G., Donaldson, K., Davis, J.M.G., Wilson, M., and Tran, C.L. 2002. Toxicity of volcanic ash from Montserrat. Institute of Occupational Medicine, Edinburgh, Report No. TM/02/01, pp. 55.

Tran, C.L., Buchanan, D., Cullen, R.T., Searl, A., Jones, A.D., and Donaldson, K. 2000. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhalation Toxicol., 12, 1113-1126.